Monday, 5 November 2012

Markets nervous about election outcome

10 hrs.

Any stock trader will tell you that if there's one thing investors hate, it's uncertainty.

Unfortunately, with President Barack Obama and Republican challenger Mitt Romney virtually tied in polls before the election Tuesday, uncertainty is one thing they are getting in spades.

"It's crazy close," says Kim Forrest, a senior equity analyst and vice president at Fort Pitt Capital, a financial management company in Pittsburgh. "It's so up in the air, it really could go either way. In the short term, the markets will be happy that it's over."

If it's over.

Wall Street could wake up on Wednesday without a winner. If the election comes down to a thin margin in a swing state ? Ohio, Iowa, New Hampshire, take your pick ? the outcome could be delayed for days or weeks.

Related: NBC poll shows Obama with narrow 48-47 margin

The closest presidential election in recent history was bad for stocks. The Standard & Poor's 500 fell as much as 8 percent during the five weeks following the 2000 election, between George W. Bush and Vice President Al Gore.

The election was Nov. 7. Gore didn't concede until Dec. 13, after the Supreme Court essentially stopped a recount of votes in Florida.?

The biggest drop for stocks came three days after the vote, when television networks retracted their call of New Mexico for Gore and labeled it too close to call. The S&P fell 2.4 percent.

The S&P closed at 1,432 on the day of the election. It fell to 1,360, a drop of 5 percent, by Dec. 13, the day that Gore conceded defeat. The Dow Jones industrial average fell from 10,952 to 10,794 over the same period.

This year, "investors would like to see, regardless of who wins or loses, a clean and quick outcome," says Jack Ablin, chief investment officer at BMO Private Bank in Chicago, who lived in Florida in 2000. "Then we can move on to our other problems."

The most prominent of those other problems is the looming so-called fiscal cliff, a combination of higher taxes and government spending cuts that will take effect unless Congress acts by Jan. 1. The total impact next year could be as high as $800 billion.

Getting the election out of the way is the first step toward resolving the issue. For many investors, backing Obama or Romney matters less than knowing which direction the country will take.

The Standard & Poor's 500 index has fallen 3.5 percent since reaching its highest point in almost five years in September, in large part because companies lowered their revenue expectations for the rest of the year.

Related: Finals jobs report unlikely to sway many voters

In the meantime, investors have tried to decide which industries would benefit from a victory for which candidate.

A Romney victory would favor financial stocks because investment taxes would be more "investor-friendly" than they would under an Obama administration, Ablin says. Financial stocks typically pay higher dividends than companies in other sectors such as technology, for example, where cash is invested for growth.

Obama has proposed raising the tax on capital gains to 20 percent from 15 percent for high-earners and leaving it at 15 percent for everyone else. Romney wants a 15 percent rate for high-earners and no tax for everyone else.

Obama would tax high-earners' dividends as ordinary income, a sizable increase for most people. As with capital gains, Romney would maintain the 15 percent rate for richer people and eliminate the tax for people who make less.

Defense stocks would also likely benefit from having the Republican as commander-in-chief because he has pledged to increase military spending, while Obama has proposed to limit the growth of defense spending.

Infrastructure and engineering companies would likely fare better after an Obama victory, while oil companies would do better under Romney, says Forrest at Fort Pitt Capital.

Bill Stone, chief investment officer at PNC Wealth Management in Philadelphia, says that regardless of the election, signs from the housing market to auto sales encourage him that companies will remain profitable and that stocks are an attractive investment, especially given low returns on other assets.

Source: http://www.nbcnews.com/business/markets-nervous-about-uncertain-election-outcome-1C6855746

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Sanofi considered moving headquarters abroad: report

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Source: http://news.yahoo.com/sanofi-considered-moving-headquarters-abroad-report-134944184--sector.html

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Sunday, 4 November 2012

Researchers find 3 unique cell-to-cell bonds

Friday, November 2, 2012

The human body has more than a trillion cells, most of them connected, cell to neighboring cells.

How, exactly, do those bonds work? What happens when a pulling force is applied to those bonds? How long before they break? Does a better understanding of all those bonds and their responses to force have implications for fighting disease?

Sanjeevi Sivasankar, an Iowa State assistant professor of physics and astronomy and an associate of the U.S. Department of Energy's Ames Laboratory, is leading a research team that's answering those questions as it studies the biomechanics and biophysics of the proteins that bond cells together.

The researchers discovered three types of bonds when they subjected common adhesion proteins (called cadherins) to a pulling force: ideal, catch and slip bonds. The three bonds react differently to that force: ideal bonds aren't affected, catch bonds last longer and slip bonds don't last as long.

The findings have just been published by the online Early Edition of the Proceedings of the National Academy of Sciences.

Sivasankar said ideal bonds ? the ones that aren't affected by the pulling force ? had not been seen in any previous experiments. The researchers discovered them as they observed catch bonds transitioning to slip bonds.

"Ideal bonds are like a nanoscale shock absorber," Sivasankar said. "They dampen all the force."

And the others?

"Catch bonds are like a nanoscale seatbelt," he said. "They become stronger when pulled. Slip bonds are more conventional; they weaken and break when tugged."

In addition to Sivasankar, the researchers publishing the discovery are Sabyasachi Rakshit, an Iowa State post-doctoral research associate in physics and astronomy and an Ames Laboratory associate; Kristine Manibog and Omer Shafraz, Iowa State doctoral students in physics and astronomy and Ames Laboratory student associates; and Yunxiang Zhang, a post-doctoral research associate for the University of California, Berkeley's California Institute for Quantitative Biosciences.

The project was supported by a $308,000 grant from the American Heart Association, a $150,000 Basil O'Connor Award from the March of Dimes Foundation and Sivasankar's Iowa State startup funds.

The researchers made their discovery by taking single-molecule force measurements with an atomic force microscope. They coated the microscope tip and surface with cadherins, lowered the tip to the surface so bonds could form, pulled the tip back, held it and measured how long the bonds lasted under a range of constant pulling force.

The researchers propose that cell binding "is a dynamic process; cadherins tailor their adhesion in response to changes in the mechanical properties of their surrounding environment," according to the paper.

When you cut your finger, for example, cells filling the wound might use catch bonds that resist the pulls and forces placed on the wound. As the forces go away with healing, the cells may transition to ideal bonds and then to slip bonds.

Sivasankar said problems with cell adhesion can lead to diseases, including cancers and cardiovascular problems.

And so Sivasankar said the research team is pursuing other studies of cell-to-cell bonds: "This is the beginning of a lot to be discovered about the role of these types of interactions in healthy physiology as well as diseases like cancer."

###

Iowa State University: http://www.iastate.edu

Thanks to Iowa State University for this article.

This press release was posted to serve as a topic for discussion. Please comment below. We try our best to only post press releases that are associated with peer reviewed scientific literature. Critical discussions of the research are appreciated. If you need help finding a link to the original article, please contact us on twitter or via e-mail.

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Source: http://www.labspaces.net/125015/Researchers_find___unique_cell_to_cell_bonds

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Report: Car bomb hits near major Damascus hotel

AMMAN, Jordan (AP) ? A car bomb exploded near a major hotel in the Syrian capital of Damascus on Sunday, wounding several people, a pro-government television station reported.

The powerful blast shook the Dama Rose hotel and shattered much of its glass, Ikhbariyeh TV reported. The hotel in the past was used by U.N. observers visiting Syria. The site of the blast is 500 meters (yards) from the army chief-of-staff's building.

The report said the bomb was planted under a car parked in an outdoor lot near the government Labor Union building. The union chief, Mohammad Azouz, told The Associated Press that at least 12 people ? all syndicate members ? were wounded by shattered glass and two of them are in critical condition.

Regional satellite stations broadcast brief clips from the capital showing a plume of white smoke rose from a building. Azouz said firefighters at the scene were putting out a blaze caused by the blast, while ambulances were taking the wounded to nearby hospitals. He said there were blood stains on the street.

In northeast Raqqa province, the state news agency SANA reported that gunmen assassinated a leading member of the ruling Baath party. It said the gunmen broke into the home of Ismail al-Hamadeh at dawn and sprayed him with bullets as he slept, killing him instantly.

Elsewhere in Syria, the army clashed with rebels in the northern cities of Idlib and Aleppo, Damascus and the southern border town of Daraa where the uprising against President Bashar Assad began in March 2011, according to the London-based activist group Syrian Observatory for Human Rights.

In the Damascus suburbs of Harasta and al-Hajira, the army and the rebel Free Syrian Army exchanged heavy fire, killing a handful of rebels, SANA said. The army destroyed some rebel vehicles fitted with machine guns, according to the report.

___

Associated Press reporter Albert Aji in Damascus, Syria, contributed to this report.

Source: http://news.yahoo.com/report-car-bomb-hits-near-major-damascus-hotel-105644320.html

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Our solar system is not quite as special as once believed

ScienceDaily (Nov. 2, 2012) ? Some 4.567 billion years ago, our solar system's planets spawned from an expansive disc of gas and dust rotating around the sun. While similar processes are witnessed in younger solar systems throughout the Milky Way, the formative stages of our own solar system were believed to have taken twice as long to occur. Now, new research lead by the Centre for Star and Planet Formation at the Natural History Museum of Denmark, University of Copenhagen, suggests otherwise. Indeed, our solar system is not quite as special as once believed.

Using improved methods of analysis of uranium and lead isotopes, the current study of primitive meteorites has enabled researchers to date the formation of two very different types of materials, so-called calcium-aluminum-rich inclusions (or CAI's for short) and chondrules, found within the same meteorite. By doing so, the chronology and therefore overall understanding of our solar system's development has been altered. The study has just been published in the scientific journal Science.

4.567 billion years -- this is how far back we must travel to experience our nascent solar system. The researchers at the University of Copenhagen Centre for Star and Planet Formation took a closer look at the first three million years of the solar system's development by analysing primitive meteorites composed of a blend of our solar system's very oldest materials. In part, the study confirmed previous analyses demonstrating that CAI's were formed during a very short period of time. The new discovery is that the so-called chondrules were formed during the first three million years of the solar system's development as well. This stands in contrast with previous assumptions asserting that chondrules only started forming roughly two million years after CAIs.

Painting a new picture of the Solar System

"By using this process to date the formation of these two very different types of materials found in the same meteorite, we are not only able to alter the chronology of our solar system's historical development, we are able to paint a new picture of our solar system's development, which is very much like the picture that other researchers have observed in other planetary systems," says James Connelly of the Centre for Star and Planet Formation.

We aren't that special...

Showing that chondrules are as old as CAIs addresses a long-standing question of why chondrule formation should be delayed by up to 2 million years after CAIs. The answer -- it is not.

"In general, we have shown that we are not quite as unique as we once thought. Our solar system closely resembles other observable planetary systems within our galaxy. In this way, our results serve to corroborate other research results which indicate that earth-like planets are more widespread in the universe than previously believed," says Professor Martin Bizzarro, head of the Centre for Star and Planet Formation.

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The above story is reprinted from materials provided by University of Copenhagen.

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Journal Reference:

  1. J. N. Connelly, M. Bizzarro, A. N. Krot, A. Nordlund, D. Wielandt, M. A. Ivanova. The Absolute Chronology and Thermal Processing of Solids in the Solar Protoplanetary Disk. Science, 2012; 338 (6107): 651 DOI: 10.1126/science.1226919

Note: If no author is given, the source is cited instead.

Disclaimer: Views expressed in this article do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/most_popular/~3/q10rk6vzp0o/121102151950.htm

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Saturday, 3 November 2012

Cristelle's Music Breaks Out of Clubs and onto Soundtracks : Music ...

LOS ANGELES, Calif. (SEND2PRESS NEWSWIRE) ? While DJs at nightclubs are using Cristelle?s ?Breakdown? to keep dance floors filled, her recordings are also playing on the soundtracks of television programs across a wide spectrum of entertainment.

Cristelle?s song ?Dance My Life Away,? the title of which seems to sum up part of her approach to the world, has had two placements. The first was in the Cinemax production of ?Femmes Fatales? and the second was in the VH1 series, ?Basketball Wives.?

There have also been two placements for Cristelle?s ?Gonna Love You,? the first in the CW series ?Shedding for the Wedding? and the second in the long-running and iconic CBS series, ?The Young and the Restless.?

?No Rush,? a song whose title is the antithesis of Cristelle?s non-stop schedule, was featured in the Lifetime network motion picture, ?The Natalee Holloway Story.?

?While making music is such a joy for me, it?s sometimes hard to concentrate on the business side of things,? Cristelle admits, ?but fortunately there?s a great team of experts who look after all the connections and placements. The success they?ve had is really exhilarating for me.?

?Working with Cristelle is exciting,? notes her producer, Peter Roberts. ?We?re all very pleased with the use of ?Breakdown? in clubs and expect that this song will start to appear on soundtracks of motion pictures and television programs along with the other great tunes that are already placed.?

Many of Cristelle?s songs reflect her upbeat personality. ?Living life to the fullest? seems to be her motto. ?I?m always an on-the-go type of girl,? says the 23-year-old singer, dancer, and model. In particular, the ?Breakdown? single celebrates the enthusiasm of youth, the headiness of love, and the continual quest for sharing good times.

About Cristelle
For Cristelle, her love of performing became evident about the time she learned to walk. She feels fortunate that her family was involved with music and the arts, ?so I was always surrounded by singers, actors, and artists,? she notes happily. Cristelle earned a spot in Los Angeles High School for the Performing Arts and spent one season with Disney On Ice performing in ?High School Musical.?

Cristelle Music Online
A music video for ?Breakdown? is now on YouTube and the single is available for sale on iTunes and Amazon. Her first album, ?Rush,? will be released later this year by BDM Records. As with the single, the producer is Peter Roberts, who has had more than 250 of his songs recorded by artists in almost every genre, including Irene Cara and jazz superstar George Benson.

More Information
For complete news and information on Cristelle, visit her website at http://www.cristellemusic.com where you?ll find her music as well as links to her social network pages.

MEDIA CONTACT:
John Scott G
jsg@gmanmarketing
818-223-8486

NEWS SOURCE: Cristelle/BDM Records

Cristelle ?Breakdown? video:

About Jesse JJ Jame

JJ Jame is a percussionist and home-brew theremin player, formerly a member of the Redondo Beach based BoyRacer.com electronica band, and a long-time electronic music fan, as well as formerly an editor for the defunct EMcult website that Christopher Simmons launched in 1997 but soon abandoned (in many ways this site, MIN, is the stepchild of that project).

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Tags: dance music, DJ, nightclub, PR, Television

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Source: http://musicindustrynewswire.com/cristelles-music-breaks-out-of-clubs-and-onto-soundtracks/

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Friday, 2 November 2012

iPad mini vs. Nexus 7: Which should you get?

iPad mini vs. Nexus 7: Which should you get?

Apple has introduced their lighter, thinner, more "concentrated" iPad mini but they certainly weren't first-to-market with a small tablet. Most recently, Google and their partner, Asus, launched the Nexus 7, the best Android tablet to date.

Still, the Nexus 7 hasn't really caught on beyond Android aficionados and gadget geeks. And that's despite it's decent build quality, ultra-modern operating system, and the full-on Google support only Nexus-class devices enjoy. It remains to be seen if Apple's small tablet will fare any better in the thus-far completely big iPad dominated market, but if you're looking for an alternative, there's very few other places to look.

So what happens when you put Apple's iPad mini up against Google and Asus' Nexus 7? Apple's engineering precision up against Google's Android power? Let's take a look.

iPad mini vs. Nexus 7: Hardware

The Nexus 7 sports a quad-core Tegra 3 processor and a 7-inch IPS display at 1280x800 resolution, which translates into 216 ppi. It has NFC, Bluetooth 3.0, and GPS built-in, and they've just added an HSPA+ option to the high end model (but not LTE, and yes, that makes a difference). It's got a 1.2 megapixel, 720p camera on front, and the back is plastic, but soft-touch to make it easy to hold on to, even one-handed.

The speaker is stereo but Google doesn't make a big deal about it. The original Nexus 7 came with 8 or 16GB of storage, but that's just been bumped to 16 or 32GB. Battery life is rated at 9 hours for video, which is accurate in my experience. (Though standby time for me has been abysmal.)

The iPad mini blends an iPod touch-like casing and internals with a decidedly iPad 2-like 4:3 screen ratio, splitting the difference in side bezel almost down the middle. The back is aluminum and the front, a 7.9-inch IPS display at 1024x768 and163 ppi. How does that compare to the physically smaller but denser Nexus 7?

The iPad mini also has a die-shrunk, dual core Apple A5 processor inside, and while there's no NFC, there is GPS on the cellular model, and there are cellular models compatible with GSM and CDMA, including HSPA+, DC-HSPA+, and LTE around the world.

The iPad mini has stereo speakers but Apple likewise doesn't advertise them, and both a front facing 1.2mp, 720p camera and a rear-facing 5mp, 1080p camera. You can get the iPad mini in black or white, and in 16, 32, or 64GB versions. Battery life is rated at 10 hours for watching videos, and iPads have traditionally met Apple's battery life claims.

So when it comes to hardware, iPad mini wins on design, manufacturing, and elegance, and Nexus 7 wins on power and screen density.

iPad mini vs. Nexus 7: Software

The Nexus 7 runs Android 4.1 Jelly Bean but should be updated shortly to Android 4.2. Jelly Bean is a great operating system, but it's still better suited for phones instead of tablets. Google claims the Nexus 7 uses a mix of phone and tablet UI, based on what's best for the task at hand. My guess is they're still searching for the right way to translate Android to tablets and we'll see it in 5.0 or some other future version. Right now, however, it's much more like a big phone than a small tablet, and that's not a bad thing -- it might even be better for some users -- but it's a different thing. Also, while Google and Project Butter have done a lot to improve interface and performance, it's still not iOS-level polished, and things like the back button are still an exercise in frustration. That said, Android is even more powerful than ever, with features and functions far beyond those available to iOS. Google Now is more than a few steps ahead of Siri, notifications are actionable, and apps can actually communicate with each other. Imagine that.

iOS 6 comes loaded on the iPad mini, and Apple still leads the industry when it comes not only to polish and consistency, but to pushing out software updates for their devices (granted, they have much fewer of them and much more control over them than anyone else in industry). You still can't do a lot of things with iOS, and that will frustrate a lot of users, especially those with edge or very specific power needs, but what you can do you can do easily. iOS 6 also has a complete, optimized tablet interface with multiple columns and features beyond what you can fit on a single phone-style interface screen. Safari for iPad is still the best mobile browser (sorry Chrome), the Home button is an amazing escape hatch for non-technical users, and the accessibility features lead the industry.

So software is a similar story to hardware. Apple writes better code and creates more cohesive, consistent user experiences than Google. But Google makes code that does more things and is more customizable than Apple. Argue that all you want, but at the end of the day iOS in invariably smoother, more intuitive, more up-to-date, and more pixel perfect than Android, yet just as invariably misses out on a lot of features Android gets early and gets stock. If you want something that's accessible and just works, iOS has the advantage. If you want something configurable that just works the way you want it to, Android wins.

iPad mini vs. Nexus 7: Services

When it comes to services that bring the internet fully to your iPad mini, Apple has iCloud, which includes iTunes in the Cloud, iTunes Match, Photo Stream, Documents in the Cloud, Find my iPhone, Find my Friends, and more. As a service goes, it's... serviceable. It backs up and syncs your data and gives you access to all of the your iTunes content. But Apple is still new to the cloud and they aren't as strong at it as they are hardware and software. At least not yet.

Google was born in the cloud. They're the biggest cloud services provider in the world. Android, in many ways, is a localized front end for Google's cloud. Now the localized part traditionally wasn't as good as Apple -- they just chucked web pages inside of apps -- but Google has been getting better code as well. Now their services not only work well, but look better and perform far better than ever before.

The twist here is that you can get almost every single Google service on the iPad mini that you can get on the Nexus 7. Now, Android has by far -- by far! -- the better Google integration of course, but the iPad mini has a surprising amount as well, including the brand new Google Search. And that's also including Gmail, Google+ YouTube, Drive, Google, etc. That's a full, robust, and increasingly good set of offerings available in Apple's App Store. (For reasons that involve the difference in business models between Apple and Google.)

So, going with the Nexus 7, you get the best Google can offer, but nothing from Apple. Going with the iPad mini, you get everything Apple and almost everything Google, but there's one more kind of service to consider -- customer service.

The Apple Store is unmatched. From buying your iPad mini, to being taught how to use it, to easily getting help with it when something goes wrong, Apple has hundreds of stores in dozens of countries. If you live anywhere near an Apple Store and your iPad mini stops working, you can go in and get it fixed, or get it swapped out for a replacement, in a matter of hours. With the Nexus 7, all you'll have is lost time and patience as you wait for Google's notoriously non-human mechanisms to process you.

If you live in the Google cloud, Nexus 7 is undeniably the better choice. If you don't, go with the iPad mini. What Apple lacks in online services, Google makes up for, and you get the best customer service in the business.

iPad mini vs. Nexus 7: Content

Apple has a tremendous advantage when it comes to content. iTunes started earlier and is now in more countries and provides more content than anyone else on the planet. Moreover, like with the services above, even if you don't like iTunes books, movies, TV shows, etc., you can also get Amazon, Netflix, Spotify, and all the other content companies right on your iPhone.

Google provides a lot of its own content now with Google Play, and you have access to enough third party content that there's no real difference. If you live in the U.S., you're almost certainly good to go. If you live outside the U.S. it can literally be the difference between being able to get legitimate content onto your phone and not (if that matters to you).

When it comes to apps, Apple used to win by default based on the sheer magnitude of numbers. That's no longer true for phones, but it is for tablets. Apple has over 275,000 tablet-optimized apps. Google has a handful. Sure, you can run the 700,000+ Android phone apps on the Nexus 7, just like you can run the 700,000+ iPhone/iPod touch apps on the iPad mini, but that's a second-class experience. Do you want a big phone or a tablet?

Apple has also become slightly more open over time, and Android apps have become much better looking and better working. You can still knock Apple for being more controlling, both in terms of what apps you can get and how those apps can interact with each other (or not), but for some users the simplicity and security of that model trumps any neck-bearded annoyance.

Now, if you already have an iPhone or iPod touch or iPad, and a lot of iOS apps that work on the iPad mini, or if you've already bought a lot of iTunes media, that can make it easier and cheaper to stick with Apple. Likewise, if you already have a lot of content from Google Play, you'll find it easier to stick with Android.

Otherwise, if you're in the U.S., you're good to go with either, and if you're outside the U.S. and really care about buying your media, check and see what's available, but Apple and the iPad mini is your safer bet.

iPad mini vs. Nexus 7: Price

The Nexus 7 is $199 for 16GB, $249 for 32GB, $299 for 32GB + HSPA+.

The iPad mini is $329 for 16GB, $429 for 32GB, and $529 for 64GB, and you can get HSPA+/LTE on all of those for an additional $130.

So, while the iPad mini is much better built, uses aluminum instead of plastic, includes extras like LTE and a 5mp rear-facing camera, etc., the Nexus 7 absolutely wins on price.

iPad mini vs. Nexus 7: The bottom line

If you want to run Android, absolutely have to have a slightly higher screen density, or don't have more than $299 in your pocket, get the Nexus 7. Otherwise, get the iPad mini. Cost isn't the same thing as value.

The iPad is almost synonymous with tablets for most people, most of the time, for very good reason. If you want a Nexus 7, you specifically want a Nexus 7. If you want a tablet, you want an iPad mini.



Source: http://feedproxy.google.com/~r/TheIphoneBlog/~3/4sxOfxK1HOU/story01.htm

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