Wednesday, 3 April 2013

White supremacists in DA death?

KAUFMAN, Texas (AP) ? Two days after a Texas district attorney and his wife were found shot to death in their home, authorities have said little about their investigation or any potential suspects.

But suspicion in the slayings shifted Monday to a white supremacist prison gang with a long history of violence and retribution that was also the focus of a December law enforcement bulletin warning that its members might try to attack police or prosecutors.

The deaths of Kaufman County District Attorney Mike McLelland and his wife were especially jarring because they happened just a couple of months after one of the county's assistant district attorneys, Mark Hasse, was killed near his courthouse office and less than two weeks after Colorado's prison chief was shot to death at his front door, apparently by a white supremacist ex-convict.

The Aryan Brotherhood of Texas has been in the state's prison system since the 1980s, when it began as a white supremacist gang that protected its members and ran illegal activities, including drug distribution, according to Terry Pelz, a former Texas prison warden and expert on the gang.

The group is now believed to have more than 4,000 members in and out of prison who deal in a variety of criminal enterprises, including prostitution, robbery and murder.

It has a paramilitary structure with five factions around the state, Pelz said. Each faction has a general, who is part of a steering committee known as the "Wheel," which controls all criminal aspects of the gang, according to court papers.

Four top leaders of the group were indicted in October for crimes ranging from murder to drug trafficking. Two months later, authorities issued the bulletin warning that the gang might try to retaliate against law enforcement for the investigation that also led to the arrest of 30 other members.

At the time, prosecutors called the indictments "a devastating blow to the leadership" of the gang. Pelz said the indictments might have fragmented the gang's leadership.

Hasse's Jan. 31 death came on the same day as the first guilty pleas were entered in the indictment. No arrests have been made in his killing.

McLelland was part of a multi-agency task force that investigated the Aryan Brotherhood with help from the FBI, the Drug Enforcement Administration and police in Houston and Fort Worth.

Detectives have declined to say if the Aryan Brotherhood is the focus of their investigation, but the state Department of Public Safety bulletin warned that the group is "involved in issuing orders to inflict 'mass casualties or death' to law enforcement officials involved in the recent case."

Killing law enforcement representatives would be uncharacteristic of the group, Pelz said.

"They don't go around killing officials," he said. "They don't draw heat upon themselves."

But Pelz, who worked in the Texas prison system for 21 years, said the gang has a history of threatening officials and of killing its own members or rivals.

The 18-count indictment accused gang members of being involved in three murders of rival gang members, multiple attempted murders, kidnappings, assaults and conspiracy to distribute methamphetamine and cocaine.

Some of the attempted murders in the indictment involved gang members who were targeted for not following orders or rules or who were believed to be cooperating with law enforcement. The indictment also alleges that gang members discussed killing a police officer in 2008 and allegedly ordered a subordinate gang member to kill a prospect "and to return the victim's severed finger as a trophy."

Meanwhile, law enforcement agencies throughout Texas were on high alert, and steps were being taken to better protect DAs and their staffs.

In Kaufman County, deputies escorted some employees into the courthouse Monday after the slayings stirred fears that other public employees could be targeted. Law enforcement officers were seen patrolling outside the courthouse, one holding a semi-automatic weapon, while others walked around inside.

McLelland was the 13th prosecutor killed in the U.S. since the National Association of District Attorneys began keeping count in the 1960s.

Deputies were called to the McLelland home by relatives and friends who had been unable to reach the pair, according to a search warrant affidavit.

When they arrived, investigators found the couple had been shot multiple times. Cartridge casings were scattered near their bodies, the affidavit said.

Authorities have not discussed a motive.

The slayings also called to mind the death of Colorado's corrections director, Tom Clements, who was killed March 19 when he answered the doorbell at his home outside Colorado Springs. Two days later, Evan Spencer Ebel, a white supremacist and former Colorado inmate suspected of shooting Clements, died in a shootout with Texas deputies about 100 miles from Kaufman.

In an Associated Press interview shortly after the Colorado killing, McLelland himself raised the possibility that Hasse was gunned down by a white supremacist gang.

After that attack, McLelland said, he carried a gun everywhere around town, even when walking his dog. He figured assassins were more likely to try to attack him outside. He said he had warned all his employees to be constantly on the alert.

___

Lozano reported from Houston. Associated Press Writer Angela K. Brown in Fort Worth also contributed to this report.

Source: http://news.yahoo.com/suspicion-da-death-shifts-white-supremacists-223215989.html

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Tuesday, 2 April 2013

Official: Obama to announce brain mapping project

WASHINGTON (AP) ? President Barack Obama is proposing a new investment into research to map the human brain in hopes of unlocking some of its mysteries, a senior administration official says.

The president planned to propose a $100 million investment for next year during an announcement at the White House Tuesday morning, the official said.

Obama mentioned the idea in his State of the Union address, comparing the potential to the Human Genome Project that mapped DNA.

"Every dollar we invested to map the human genome returned $140 to our economy. Every dollar," Obama said in the address to Congress in February. "Today, our scientists are mapping the human brain to unlock the answers to Alzheimer's."

Obama wants the research to involve private institutions as well as government agencies, including the National Institutes of Health, the Defense Advanced Research Projects Agency and the National Science Foundation. It will require the development of new technology that can record the electrical activity of more neurons in the brain and a study of the ethical implications of the advancements.

The official spoke on a condition of anonymity because the president had not yet announced the plan. It was first reported by The New York Times.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/89ae8247abe8493fae24405546e9a1aa/Article_2013-04-02-US-Obama-Human-Brain/id-8c04363488a24b89a8d80c9ad9f9ae5a

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Lawyer: India's Supreme Court rejects Novartis AG's right to patent new version of cancer drug

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Source: http://news.yahoo.com/lawyer-indias-supreme-court-rejects-052234007.html

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New drug target companion prognostic test for hormone therapy resistance

Apr. 1, 2013 ? A team of international cancer researchers led by Dr. Mathieu Lupien at the Princess Margaret Cancer Centre, University Health Network, has identified the signalling pathway that is over-activated in estrogen receptor (ER)-positive breast cancer cells that are resistant to hormone therapies such as tamoxifen, aromatase inhibitors or fulvestrant.

Resistance to hormone therapy is reported in almost half of ER-positive breast cancer patients and no cure is currently available. The fact that the pathway, called Notch, is a drug target creates hope for a new therapy.

The findings, published online today in the Proceedings of the National Academy of Sciences, "provide a new therapeutic target against hormone therapy-resistant breast cancers and a companion test to identify tumours that would become resistant" says Dr. Lupien, a scientist at the Ontario Cancer Institute, the research arm of the cancer centre, and an Assistant Professor in the Department of Medial Biophysics, University of Toronto. He specializes in epigenetics of hormone-dependent cancers -- the study of non-genetic determinants of cellular identity that can also be altered to initiate or modify disease.

"In studying the epigenetics of hormone therapy resistance, we discovered that breast cancer cells behave like a chameleon. Indeed, as the chameleon changes its skin colour to camouflage itself and evade predators," says Dr. Lupien, "breast cancer cells change the appearance of their DNA through epigenetics to evade, in this case, hormone therapy." In so doing, hormone therapy-resistant breast cancer cells highlight regions of their DNA related to the Notch pathway.

At the molecular level, the research team characterized the epigenetic appearances of the DNA of drug-resistant and drug-responsive breast cancer cells. The team discovered that the Notch signaling pathway plays the predominant role in drug-resistant breast cancer cells even if cells remain positive for ER.

"This is a highly promising discovery that could rapidly translate in the clinic. Drugs against the Notch pathway are available." says Dr. Lupien. The key will be to test the efficacy of these drugs against hormone therapy resistance in breast cancer.

The research was funded by the National Cancer Institute, the American Cancer Society and the Ontario Institute for Cancer Research. Dr. Lupien's research is also supported by The Princess Margaret Cancer Foundation.

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The above story is reprinted from materials provided by University Health Network.

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Journal Reference:

  1. Luca Magnani, Alexander Stoeck, Xiaoyang Zhang, Andr?s L?nczky, Anne C. Mirabella, Tian-Li Wang, Bal?zs Gyorffy, and Mathieu Lupien. Genome-wide reprogramming of the chromatin landscape underlies endocrine therapy resistance in breast cancer. Proceedings of the National Academy of Sciences, 2013; DOI: 10.1073/pnas.1219992110

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/~3/pUzj0i7pl44/130401151035.htm

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Monday, 1 April 2013

J.C. Penney's home revamp is make or break for CEO Johnson

By Phil Wahba

(Reuters) - It's crunch time for J.C. Penney Co Inc Chief Executive Ron Johnson.

The struggling department store chain is poised to open the first of its new home goods boutiques on April 5, a launch that Johnson himself has called "pivotal" to his efforts to revive Penney.

Once the go-to place for home products like window treatments and bath towels, Penney's customer traffic fell 13 percent in fiscal 2012 while revenues plummeted 25 percent, the first full year with Johnson at the helm. For seven years running, home goods have been Penney's worst performing category.

Johnson, who first made his name in retail at Target Corp's home goods business in the 1990s and pioneered the "cheap chic" esthetic, faces pressure from Penney's board to reverse sliding sales or risk losing his job.

Penney's new home goods section, to appear at 500 of its 1,100 stores, will be anchored by designers such as Jonathan Adler and Michael Graves and have 20 shops by the time the renovations are done in late May. Sir Terence Conran's furniture shops will be in 225 stores.

Other launch brands set for April include coffee-press maker Bodum. A legal dispute with rival Macy's Inc means it will, for now, only sell some of the goods that Martha Stewart Living Omnimedia Inc had originally planned for Penney. Her line will be called MarthaCelebrations and include: food, rugs, mirrors and greeting cards.

Home products are a magnet for department store shoppers. After years of neglect and uninspired, deeply discounted goods, as well as a focus on improving its fashion selection, many Penney customers went to rivals.

The home category accounted for 12 percent of Penney's sales in 2012, compared to 21 percent six years earlier, and sales per square foot in home goods have fallen by more than half in that time. In 2008, Penney logged about $3.7 billion in home goods sales, just below Macy's. By 2012, they had fallen to roughly one-third of Macy's levels.

"They're going to have a hard time getting back people they've disappointed," said Kathy Gersch, a former Nordstrom executive and co-founder of Kotter International, which helps companies implement strategies.

Penney is also up against specialty chains like TJX Cos Inc's fast-growing HomeGoods, which has almost 400 stores and which the company says could eventually have 850 locations. HomeGoods sales rose 18 percent in 2012 to $2.66 billion, almost twice as much as Penney's home goods sales.

"There are a lot of retailers going after that business," said NPD Group analyst Debra Mednick.

SHOPPERS ON A BUDGET

The new home section is part of Johnson's plan to remake Penney's larger stores into collections of boutiques-within-a-store. Some 30 percent of the space at the 500 stores will have been converted by the end of May.

Penney's fashion boutiques have reported promising early results - but not enough to convince investors. Penney's shares are down 23 percent so far this year.

The new home area will occupy up to 19,000 square feet of space, or more than twice the size of a typical Williams-Sonoma store. Penney said it intends to ultimately have about 20 branded shops in its home sections.

Adler told Reuters his "Happy Chic" collection for Penney will have "noticeably" lower prices than his other collections. For example, one square decorative pillow will go for $35, whereas elsewhere his pillows command $110 for something similar.

Johnson has said the average Penney home shopper is older than her counterpart at Wal-Mart , Macy's, Target and Kohl's , explaining the desire to pull in younger shoppers with brands retail experts have said were attractive.

A successful home goods business, however, has to attract the head of a household, more than a young urbanite. Paul Rutenis, the executive overseeing the overhaul of the home business, said beyond the boutiques, Penney will also organize home products by category at a variety of prices to appeal to a broad range of shoppers to do just that.

Penney will also regularly hold sales events and offer discounts, having learned a painful lesson last year when it unsuccessfully tried to wean its shoppers off of those tactics.

Newell Rubbermaid Inc CEO Mike Polk recently said Penney has had a tough year, and that has hurt his company's sales of Calphalon cookware and Levolor window treatments.

"I would expect that that reset doesn't get traction until the second half of the year," Polk said.

(Reporting by Phil Wahba in New York. Additional reporting by Jessica Wohl in Chicago; Editing by Ben Berkowitz, Tiffany Wu and Leslie Gevirtz)

Source: http://news.yahoo.com/j-c-penneys-home-revamp-break-ceo-johnson-110256558--sector.html

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April Flowers? Auction of Seattle Marijuana Domain Names On Now ...

THC Web Design, a?cannabis industry web design?start-up based in Washington State, has announced the auction of one of their domain names. ?BestMarijuanaSeattle.com?(along with BestMarijuanaSeattle.net) which is up for bid at a ?for blind auction March 30th through April 12th, with the winning bidder to be notified on April 13th. The blind auction format allows for anonymity among bidders, and the identity of the winning bidder will not be made public by THC Web Design. A minimum bid of $1000 is required for participation.

THC Web Design owns a large number of competitive geographic domain names for the legal marijuana industry coming to Washington and Colorado, and will soon be offering web development services to legal cannabis businesses.

Among?SEO?experts, such as?THC Search Engine Optimization, an affiliated firm dedicated to obtaining ?higher rankings? for its clients, ?it is widely acknowledged that having a competitive domain name is one of the best ways to achieve organic first-place rankings in search engines. In the cannabis market coming to Washington State next year, recreational pot smokers will be able to walk into a retail outlet and buy cannabis flowers, edibles, and other infused products. The developers at THC Web Design believe that the internet will be the primary means that consumers will use to find these new retail outlets.

?The problem facing business owners in this new market,? said Noel Abbott, founder of THC Web Design, ?is how they are going to advertise their product responsibly. The details of I-502 are still being fleshed out, but there will definitely be restrictions on signage, window display marketing, and storefront location. Passing out flyers can run the risk of influencing underage people if those flyers wind up in the wrong place. By focusing marketing efforts online through competitive websites and social media, dispensary owners will be able to target only the people who are searching for their product, which is the most responsible approach.?

BestMarijuanaSeattle.com is the first of many domains owned by THC Web Design that will go up for auction. Interested parties may email thcmediagroupcontact(at)gmail(dot)com to place and confirm their bid, or to ask questions about future domains that will go up for auction. A partial list of available domain names is available on the THC Web Design website.

According to?The Atlantic, last November Washington and Colorado became the first states in the USA to legalize and regulate marijuana growing, processing, and retail for recreational consumption. At the federal level, marijuana is still considered an illegal substance with no acknowledged medical applications, though 18 states have legalized cannabis for medical purposes. The federal stance toward full-scale recreational legalization in Washington and Colorado has yet to be made clear, but the states are bound by the initiatives passed by voters, and the new industry is coming later this year. [24x7]

Easter Grass? No, It?s Washington State?s Grass Consultant

In a related story,?Washington has named its first official marijuana consultant: his name is Mark Kleiman and his think-tank is Botec Analysis Corporation.

The job is the first of its kind: help the state develop its new fledgling recreational marijuana industry.

Kleiman, a graduate of Harvard?s Kennedy School of Government, teaches public policy at the University?of California, Los Angeles. His team is made up of 30 policy experts, scientists and seasoned cannabis?growers. It includes a Nobel Prize winning economist, former President Nixon?s drug czar and a Harvard?professor.

The term ?Pot Czar? isn?t quite appropriate for Botec. The team will provide advice to the state?s Liquor Control Board, but the board itself will be making the rules for the new industry. What the state needs is help understanding four aspects of weed: harvesting, quality testing, pricing and rules. [24x7]

Related posts:

  1. Seattle Domain Tools Auction Sets Record
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  3. Meet the New Leader of Microsoft Windows: Julie Larson-Green
  4. Startup On Ramp: TiE Seattle Names 2013?s Startup of the Month
  5. City of Seattle Start-Up Weekend, April 27-29

Category: What's Brewing?

Source: http://www.seattle24x7.com/community/whats-brewing/2013/04/01/april-flowers-auction-of-seattle-marijuana-domain-names-on-now-pot-leader-picked/

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After Newtown: What mental health system? (Washington Post)

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